Cat Dog

The show details the misadventures of CatDog, a conjoined cat and dog. Despite sharing a body, Cat and Dog are wildly different: Cat is worldly wise and suave, contrasting with the optimistic and childlike Dog. Though they are of different species, the duo refers to themselves as "brothers".

Because of their strange condition, CatDog are often harassed by the Greaser Dogs, a trio of tough hoods, and their neighbor, Winslow, a devious blue rat.

Albie Hecht, Nickelodeon's senior vice president of worldwide productions, said that the creators planned for the show to "really play off of kids' sympathies" by portraying the characters as experiencing "have the worst of both worlds.

^Character

• Dog

Dog, a dog, generally acts as the normal canine; loyal to a fault, very energetic, and easily distracted. He is often a voice of reason for Cat, who can be highly unscrupulous in his tasks. Unlike Cat, he does not care for cleanliness, preferring instead to ravage trash cans for food. His catchphrase is "Hi Ho diggity". He is voiced by Tom Kenny.

• Cat

Cat, a cat, desires fame and fortune, and is prone to go to extravagant lengths in order to achieve them despite Dog's warnings. He is a stickler for cleanliness, yet is highly hydrophobic, like all cats are. He is voiced by Jim Cummings.

• Cliff

The leader of The Greaser Dogs. Cliff acts belligerent in order to maintain his tough image, but has a very vulnerable side which Cat and Dog sometimes exploit. Also voiced by Tom Kenny.

• Shriek

The second-in-command of the Greasers, she struggles to distance herself from her privileged background with a tomboyish demeanor. Because of this, she must often remind other characters of her femininity. Shriek has an unrequited crush on Dog, which is said to prevent her from harming him during CatDog's routine beatings at the Greasers' hands. She is voiced by Maria Bamford.

• Lube

Real name Ignatius, he is very unintelligent and sometimes speaks in non sequiturs. Lube is the workhorse of the Greasers, often doing tasks which Shriek and Cliff have the sense to shirk. Lube is a skilled auto mechanic, hence his nickname. He is voiced by Carlos Alazraqui.

• Winslow Oddfellow

A blue mouse who lives in CatDog's home. Constantly sarcastic and critical, he is a constant annoyance to Cat and Dog but remains their friend.

• Rancid Rabbit

Rancid Rabbit often serves as an antagonist to CatDog and the Greasers, appearing in numerous roles throughout the series. He is highly manipulative and greedy, and has a very short temper. His catchphrases are What, what, what, and Leaping Lumbago. Rancid is voiced by Billy West.